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Immunization by irradiated mosquitoes can protect against malaria.(Brief Article)
2002 JUN 12 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Volunteers who underwent bites from thousands of irradiated mosquitoes harboring Plasmodium falciparum sporozoites were immunized against malaria, researchers in the U.S. report.
Effective immunization against malaria is important because of the widespread prevalence of the disease.
S.L. Hoffman, Celera Genomics, Rockville, Maryland, and colleagues recruited 11 volunteers to test the efficacy of immunization by exposure to irradiated mosquito bites.
The subjects were exposed to thousands of mosquitoes known to carry strain NF54 or clone 3D7/NF54 of Plasmodium falciparum the sporozoan that causes malaria. Each subject received 1001-2927 mosquito bites. Investigators then challenged the patients' immune systems through exposure to the bites of mosquitoes infected with Plasmodium falciparum (Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites, Journal of Infectious Diseases, 2002;185(8):1155-1164).
A challenge 10 weeks after immunization revealed that one subject was not protected. Two to 9 weeks after immunization, 10 volunteers received the immunological challenge. All subjects were protected against malaria. Investigators rechallenged five of these subjects 23-42 weeks after ...
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Source: HighBeam Research, Immunization by irradiated mosquitoes can protect against...