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Low-grade cervical lesions likely to regress spontaneously in adolescent women.(Brief Article)
2002 JUN 6 - (NewsRx.com & NewsRx.net) -- Low-grade dysplasia found on Pap smears is likely to regress spontaneously in adolescent women, a University of California San Francisco (UCSF) study shows
Teenage and young adult women who develop low-grade, benign lesions in the cervix due to human papillomavirus (HPV) have a 95% or better chance that the lesions will clear up on their own and not progress to a more advanced stage, according to the study.
The results were reported on May 4, at the annual meeting of the Pediatric Academic Societies in Baltimore. They come from the longest-running longitudinal study of adolescent and young women and human papillomavirus, a National Cancer Institute-sponsored project now in its 12th year. It is led by Anna-Barbara Moscicki, MD, UCSF professor of pediatrics and an expert in HPV and adolescent medicine at UCSF Children's Hospital.
The researchers studied 187 adolescents ages 13 to 22 years who were diagnosed with low-grade squamous intraepithelial lesions (LSILs). The women, from a range of ethnic and socioeconomic backgrounds, were followed every four months to determine the presence of lesions. Only 4% of the women had persistent LSILs that had not regressed, or cleared up, after 3 years. Most lesions regressed within a median time of 3 months. A few of the original group had insufficient follow-up information to determine the outcome, leading to a statistical estimate of a 95% regression rate.
Other studies have shown that as many as 20-50% of adult women with LSILs will have a persistent lesion or one that progresses to a higher grade. Progression of lesions is considered to be a step toward cervical cancer, so even though LSILs themselves are benign, doctors recommend that these women get frequent checkups to watch for changes in cervical cells. Treatment is recommended if the lesion persists longer than 18-24 months or if it progresses.
"For young women in their teens and 20s, the picture is not the same," Moscicki said. In addition to the data showing that LSILs tend to clear up spontaneously, earlier results from the ...
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