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Use of high dose hepatitis A, hepatitis B vaccine in India needs evaluation.(Brief Article)
2002 JUN 5 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Given the emerging number of hepatitis A virus (HAV) infections in India, medical personnel are urging greater use of vaccine prevention strategies, especially among children. One of those strategies would include the use of a high dose hepatitis A, hepatitis B combination vaccine, entailing the need for only two injections. However, more evaluation of such a proposal is needed before a two-dose regimen can be recommended for Indian children, researchers say.
The investigators have already conducted a limited trial among youngsters in India comparing high-dose hepatitis A and hepatitis B combination vaccine with the more commonly utilized Twinrix combination vaccine, which contains lower doses of vaccine.
The children, ranging in ages between 1 and 15 years, were assigned to receive two doses of the high dose hepatitis A/B vaccine at months 0 and 6 (Group I), or three doses of Twinrix at months 0, 1, and 6 (Group II). Researchers tested the children for the formation of protective antibodies at months 1, 2, and 7.
In early tests performed at months 1 or 2, the children in Group I had higher levels of anti-HAV than those in Group II, but investigators noted those in Group II were ultimately better protected against infection at months 2 and 6, based on the results of testing for antibody levels marking seroprotection (Immunogenicity and reactogenicity of a combined high dose ...
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Source: HighBeam Research, Use of high dose hepatitis A, hepatitis B vaccine in India needs...