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Vaccine first to be proved effective in animal model.(Brief Article)
2002 JUN 5 - (NewsRx.com & NewsRx.net) -- A genetically engineered vaccine developed and tested at Cincinnati Children's Hospital Medical Center is the first to be proved effective in protecting newborns, in an animal model, against cytomegalovirus (CMV), the most common congenital viral infection in the United States.
The study was presented at the annual meeting of the Pediatric Academic Societies in Baltimore, Maryland.
The Institute of Medicine has identified CMV as one of only seven diseases for which vaccine development should be given the highest priority for research and development. In fact, CMV infection is the second most common identified cause of mental retardation in newborns, after Down syndrome. A mother can pass CMV on to her newborn baby, even if she does not feel ill herself. Unfortunately, the infant, when infected in the womb, can suffer serious consequences. CMV infection is also a leading cause of deafness in children.
Mark Schleiss, MD, a physician in the division of infectious diseases at Cincinnati Children's and lead author of the study, discovered a key gene in guinea pig CMV in the mid-1990s that became the basis for development of the current vaccine. The guinea pig is the most relevant preclinical screening model for evaluating CMV vaccines, since CMV can cross to the newborn animal, just as it does in newborn infants.
In the current study, the cloned, recombinant vaccine proved to be effective in the guinea pig model in preventing transmission of CMV from mothers to their offspring.
"Although the CMV virus contains hundreds of genes, the most important ones to target for vaccine development are those that encode, or carry the genetic blueprint, for the outer protein coat of the virus, the ...
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