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Factor in breast milk stimulates vascularization of newborn intestinal tract.(erythropoietin )(Brief Article)
2002 MAY 30 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - A hormone found in human breast milk may be partially responsible for neovascularization of the newborn gastrointestinal tract.
Because human erythropoietin has been identified in breast milk and its receptors have been detected in the mucosal layers of the newborn intestine, researchers at the University of Wisconsin in Madison believe it may play a role in newborn intestinal vascularization.
"Our study is the first to examine the effects of recombinant erythropoietin (rhEPO) on the endothelium of the neonatal gastrointestinal tract," R.A. Ashley and colleagues, University of Wisconsin, Madison noted.
Ashley and coauthors emphasized in a recent issue of Pediatric Research that EPO is a multifaceted hormone, stimulating angiogenesis and vasculogenesis as well as endothelial cell growth. With the use of cells acquired from the mesentery of neonatal rats and grown in Matrigel or collagen assays, Ashley's team has characterized how EPO might be responsible for equivalent vessel growth in human newborns.
They said that a concentration of 50 IU/ml of human rhEPO was sufficient to stimulate both maximal proliferation and tubule formation in rodent microvascular ...
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Source: HighBeam Research, Factor in breast milk stimulates vascularization of newborn...