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Transfection strategy improves dendritic cell-based tumor suppression.(Brief Article)
2002 MAY 29 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - A strategy of cotransfecting dendritic cells with lymphotactin gene and melanoma antigen can enhance the way the cells target melanoma tumor growth.
Several studies have shown where dendritic cells hold the potential for being powerful tumor vaccines. Study authors say that lymphotactin (Lptn), a chemoattractant for T cells and natural killer cells, increases the anticancer effect of T cells and boosts immune system responsiveness to cancer cell challenge in murine models of established melanoma when it is transfected along with melanoma-associated antigen gp100 into murine bone marrow dendritic cells.
D.J. Xia and colleagues, Zhejiang University, Hanzhou, China, found that in mice immunized with the Lptn/gp100-transfected dendritic cells (DC), cytotoxic T lymphocyte activity increased significantly, with natural killer (NK) cell activity increasing to a lesser extent. In addition, the study team detected significantly increased levels of two cytokines associated with antigen processing, interleukin (IL)-2 and interferon-(gamma).
In contrast, murine models inoculated with normal saline or with dendritic cells encoding for Lptn alone, gp100 alone, or control genes did not display such marked changes (Lymphotactic contransfection enhances the therapeutic efficacy of dendritic cells genetically modified ...
- Dendritic cells tied to psoriasis.(News)
- Magazine article from: Skin & Allergy News McNamara, Damian March 1, 2006 700+ words
...FLA. -- Recent research implicates dendritic cells in the pathogenesis of psoriasis and...promise by halting cytokines produced by dendritic cells, he noted. Psoriasis is widely known...published since 2003) suggest that dendritic cells also play a role. Researchers believe...
- IL-10-treated dendritic cells may induce GVHD risk.
- Newspaper article from: Blood Weekly May 6, 2004 700+ words
...amp; NewsRx.net) -- Dendritic cells treated with interleukin...IL-10-treated immature dendritic cells in the first mixed leukocyte...were cultured with mature dendritic cells of the same origin as IL...
- Dendritic cells heterogeneity and its role in cancer immunity.(Review Article)
- Magazine article from: Journal of Cancer Research and Therapeutics Kah-Wai, Lin Jacek, Tabarkiewicz Jacek, Rolinski April 1, 2006 700+ words
...Tabarkiewicz. Jacek, Rolinski. Jacek Dendritic cells are the most potent 'professional...primary immune response initiation. Dendritic cells originate from bone marrow progenitors...subsequently give rise to immature dendritic cells, which reside in peripheral tissues...
- FLT3 LIGAND STIMULATES GROWTH OF DENDRITIC CELLS
- Press release article from: PR Newswire November 30, 1995 700+ words
...been shown to promote the growth of dendritic cells, a formerly elusive type of cell...now, research into the utility of dendritic cells has been hampered because these cells...large numbers of functionally mature dendritic cells. "Dendritic cells could be quite...
- Nonprimed dendritic cells enhance immune response.(Brief Article)
- Newspaper article from: Vaccine Weekly June 19, 2002 700+ words
...writer - The addition of nonprimed dendritic cells to the same site targeted by the MUC1...researchers isolated activated nonprimed dendritic cells from syngeneic mice. Tumor growth...survival time was extended when the dendritic cells were simultaneously delivered to the...
- Scientists describe how dendritic cells grow up to take on foreign invaders.
- Newspaper article from: Proteomics Weekly March 24, 2003 700+ words
...Acting as the body's sentinels, dendritic cells are constantly on the lookout for...yet to be explained, only mature dendritic cells process and accumulate these threatening...fueled an interest in using activated dendritic cells to fight cancer and other diseases...
- Dendritic Cells a Potential Adjuvant for CD8(+) T-Cell Clearance.(Brief...
- Newspaper article from: Vaccine Weekly June 7, 2000 700+ words
...University School of Medicine suggest that dendritic cells may prove to be important adjuvants...Drake, looked at both macrophages and dendritic cells in their desire to learn which antigen...induce CD8(+) T cells. "Although dendritic cells and macrophages both supported productive...
- Dendritic Cells Can Be Derived From Malignant Cells.
- Newspaper article from: Blood Weekly August 16, 2001 700+ words
...Researchers in Japan have shown that dendritic cells can be created from leukemia cell...immunotherapy, we attempted to generate dendritic cells from leukemia cells in patients with...and say that these tumor-derived dendritic cells may be able to provoke action from...