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Extra cytokines can improve idiotype vaccination efficacy.(Brief Article)
2002 MAY 29 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Germany say that they have found a way to improve the benefits of idiotype vaccination for multiple myeloma patients.
"Idiotype (Id) vaccination provides an innovative treatment modality against B-cell malignancies," explained Dr. Matthias Zeis and colleagues at University of Kiel and the University of Leipzig. "In multiple myeloma patients, however, the antitumoral potential of this immunotherapeutic concept is limited."
The addition of interleukin (IL)-2 to the postvaccination regimen enhanced tumor regression and survival in mice, Zeis and coauthors found.
The researchers injected Balb/c mice with 1-5x10[superscript]5 cells expressing an immunoglobulin (Ig) idiotype protein specific to HOPC myeloma cells. Animals who were subsequently given either Flt3 ligand (Flt3-L), IL-2, or Ig[superscript]HOPC alone did not realize significant benefits from treatment, they said.
Myeloma-specific Ig protein with IL-2 produced complete responses in 27% of the study animals, while Ig[superscript]HOPC with Flt3-L induced tumor rejection in more than 40% of treated mice. However, the combination of all three agents enabled more than 80% of study animals to survive disease-free for at least 6 ...
- Extra cytokines can improve idiotype vaccination efficacy.(multiple myeloma)
- Newspaper article from: Cancer Weekly May 28, 2002 700+ words
...effectiveness of idiotype vaccination induced by the...of Flt3-L and IL-2 can be used...Interleukin (IL)-2 can improve the benefits of idiotype vaccination for multiple myeloma...However, using IL-2 in addition...
- Extra cytokines can improve idiotype vaccination efficacy.(Brief Article)
- Newspaper article from: Immunotherapy Weekly May 29, 2002 700+ words
...effectiveness of idiotype vaccination induced by the...of Flt3-L and IL-2 can be used...Interleukin (IL)-2 can improve the benefits of idiotype vaccination for multiple myeloma...However, using IL-2 in addition...
- Extra cytokines can improve idiotype vaccination efficacy.
- Newspaper article from: Blood Weekly May 30, 2002 700+ words
...effectiveness of idiotype vaccination induced by the...of Flt3-L and IL-2 can be used...Interleukin (IL)-2 can improve the benefits of idiotype vaccination for multiple myeloma...However, using IL-2 in addition...
- Combined Immunotherapy Regimen Shows Promise In Pilot Trial.(Brief Article)
- Newspaper article from: Vaccine Weekly August 8, 2001 700+ words
...B cells and interleukin 2 (IL-2), along with autologous...specific T-cells, low-dose IL-2, and a cellular vaccine...stem cell transplantation and idiotype vaccination," reported J.L. Schultze...myalgias closely related to IL-2 injections, noted Schultze...
- Combined Immunotherapy Regimen Shows Promise In Pilot Trial.
- Newspaper article from: Immunotherapy Weekly Saltmarsh, N.R. August 8, 2001 700+ words
...B cells and interleukin 2 (IL-2), along with autologous...specific T-cells, low-dose IL-2, and a cellular vaccine...stem cell transplantation and idiotype vaccination," reported J.L. Schultze...myalgias closely related to IL-2 injections, noted Schultze...
- Personalized vaccine being tested.
- Newspaper article from: Biotech Week December 18, 2002 700+ words
...the treatment of cancer. Leonard, a leading oncologist and expert on hematological malignancies, presented "Idiotype vaccination for non-Hodgkin's lymphoma" at the Chemotherapy Foundation Symposium XX in New York City. His presentation...
- Killing malignant not normal B cells important for vaccine development.
- Newspaper article from: Life Science Weekly October 19, 2004 700+ words
...important for vaccine development. According to recent research from the United States, "A major limitation of idiotype vaccination is the requirement for patient-specific reagents. This could be overcome using shared framework region peptides...
- Collaboration announced for experimental vaccine.
- Newspaper article from: Vaccine Weekly November 13, 2002 700+ words
...supporting this study from the U.S. National Institutes of Health, Grant Number CA49605, Project 6, titled, "Idiotype vaccination following allogeneic transplantation for the treatment of multiple myeloma." "This collaboration represents...