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Agent renders hepatitis B vaccine more effective in hemodialysis patients.(Brief Article)

Vaccine Weekly

| May 29, 2002 | Nichols, Sonia | COPYRIGHT 2002 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2002 MAY 29 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - The authors of a new study have concluded AM3 (Inmunoferon) enhances the ability of kidney disease patients on hemodialysis to develop long-term protective immunity against hepatitis B virus (HBV) infection after their receiving HBV vaccine.

"Patients with end-stage renal disease undergoing hemodialysis have severe alterations in cell-mediated immunity that increases their risk of contracting chronic HBV infection and decreases their protective responses to HBV vaccine," Rafael Perez-Garcia, Gregorio Maranon Hospital, Madrid, Spain, described in Kidney International.

For that reason, Perez-Garcia and colleagues studied whether or not AM3, an immune system modulator that stimulates humoral response, had the ability to boost HBV vaccine effectiveness in kidney disease patients on long-term dialysis.

The authors of the multicenter vaccine trial administered a four dose regimen of DNA recombinant vaccine to more than 200 study participants. On the 15th day before the first vaccine dose was administered, study volunteers began taking AM3 or a placebo for a period of a month.

"The placebo and AM3-treated groups had comparable seroconversion and protective response rates 1 month after the final vaccine dose," Perez-Garcia and ...

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Source: HighBeam Research, Agent renders hepatitis B vaccine more effective in hemodialysis...

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