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High hepatitis C virus load negates effective response to hepatitis B vaccine.(Brief Article)
2002 MAY 29 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - People infected with a high hepatitis C virus (HCV) viral load may not develop protective titers after receiving hepatitis B virus (HBV) vaccine.
The authors of a multicenter study that was carried out in France argue that even after receiving three doses of HBV vaccine, people with chronic hepatitis C may develop antibody to hepatitis B surface antigen (anti-HBs) titers that fall well short of providing protective immunity.
"Seventy-seven patients with histologically proven chronic hepatitis C without cirrhosis were included in a prospective trial and matched for sex and age to 231 healthy adult subjects," described Vincent Leroy an investigator of the Department of Hepatogastroenterology, UPRES-A CNRS, Grenoble, France, and other members of the French national research consortium.
Whereas only 63.3% of those with chronic hepatitis C responded to vaccination, 93.9% of the uninfected, healthy controls did. Subsequent to receiving the third injection of the three dose series, average anti-HBs titers were only 156 [plus-or-minus sign] 260 mIU/ml in the chronic hepatitis group but 615 [plus-or-minus sign] 435 mIU/ml in the control group.
"Chronic hepatitis C patients who were nonresponders to vaccination had significantly higher viral load than responders to vaccination," Leroy and coauthors noted. In fact, statistical analysis showed an inverse correlation between viral load and HBV antibody titer among those with HCV infection (The antibody response to ...
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Source: HighBeam Research, High hepatitis C virus load negates effective response to hepatitis B...