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Cells expressing interleukin-2 arrest cancer growth and boost tumor immunity.(Brief Article)
2002 MAY 22 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Fibroblasts genetically engineered to express interleukin (IL)-2 cause tumor cell growth inhibition and protect against the formation of new brain tumors.
Medical researchers at Rush Medical College in Chicago, Illinois, have used the cells to successfully treat murine models with established glioma and prevent cerebral breast cancer establishment, according to a report in the May 2002 issue of Cancer Gene Therapy.
Terry Lichtor and colleagues reported that as a result of treating mice with allogeneic/syngeneic fibroblasts expressing IL-2 who bore established, growing glioma tumors, survival was significantly extended.
The tumor therapy went a step further though, delaying and even inhibiting the formation of new tumors in animals injected with cancer cells. "Fifty percent of the animals pretreated with IL-2-secreting fibroblasts injected subsequently with G1261 glioma cells did not develop a tumor, whereas all of the animals injected with glioma cells alone and 92% of those treated with nonsecreting fibroblasts eventually died," Lichtor and coauthors said.
The investigators said the therapy also induced long-term immunity, because challenge experiments showed that treated animals rechallenged with tumor cells lived longer as compared with naive animals (Application of interleukin-2-secreting syngeneic/allogeneic fibroblasts in the treatment of primary and ...
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Source: HighBeam Research, Cells expressing interleukin-2 arrest cancer growth and boost tumor...