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New mutated gene identified.(breast cancer)(Brief Article)
2002 MAY 23 - (NewsRx.com & NewsRx.net) -- Researchers have identified a gene that when mutated can lead to an elevated but modest risk of breast cancer.
The altered gene, called CHEK2 or CHK2, can double the estimated 13% lifetime risk of breast cancer that U.S. women face, researchers said.
About 1% of people - both women and men - carry the mutated gene.
Carrying it does not necessarily mean someone is destined to develop breast cancer, the scientists stressed. Instead, the risk is comparable to that faced by women who have a mother or sister with breast cancer, who never have children or who experience menopause at a later age.
"CHK2 is not something anyone should go out and get tested for," said Michael Stratton, of the Institute of Cancer Research in London. Stratton is coauthor of a report detailing the finding published online April 21, 2002 by the journal Nature Genetics.
The gene is also estimated to increase the risk of breast cancer in men tenfold. However, the cancer remains extremely rare in men, accounting for less than 1% of all breast cancer cases.
A pair of genes - BRCA1 and BRCA2 - remain the only genes linked to a significantly elevated risk of breast cancer. Carriers of those genes face a risk of developing inherited ...
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Source: HighBeam Research, New mutated gene identified.(breast cancer)(Brief Article)