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Pilot study may offer promise of a marker.(for early-stage ovarian cancer)(Brief Article)
2002 MAY 23 - (NewsRx.com & NewsRx.net) -- Each year, there are more than 27,000 new cases of ovarian cancer and 14,000 deaths due to this deadly disease. Sadly, preventative measures cannot help decrease these numbers in ovarian cancer because there are no symptoms in early stage disease, no lack of readily recognizable and detectable precursor lesions, and the no specific and sensitive screening tests. Consequently, in more than 75% of patients with epithelial carcinoma of the ovary, retroperitoneal or intra-abdominal spread is present at diagnosis.
The atrial natriuretic peptide (ANP) influences the tone and caliber of blood vessels and has a potential role in modulating volume homeostasis, i.e., the state of equilibrium in the body with respect to various functions and to the chemical compositions of the fluids and tissues. ANP is secreted by atrial myocytes as a 126 aminoacid molecule and divided into different fragments, namely proANP(1-30) (NtANP), proANP(31-67) (mdANP), proANP(79-98) and the active ANP(99-126).
Similar properties have been reported in previous research studies for ANP and proANP-(1-30). A University of South Florida research finding demonstrated that plasma ANP levels in gynecologic cancer patients were significantly higher than those in healthy, nonpregnant women. Now, physiologists from the same institution have attempted to extend their original observations on ANP in gynecologic malignancy, in particular to examine the possible relationship between ANP and proANP-(1-30) levels in plasma and ascites fluid (serous fluid from the peritoneal cacity) in primary cancer of the ovaries.
Fourteen women undergoing primary cytoreductive surgery for ovarian carcinoma participated in this study following informed consent. On the day of surgery, blood samples were obtained prior to the induction of anesthesia and ascites was collected intraoperatively. Following centrifugation the samples were divided into equal parts and stored at -70[degree sign]C until tested. The extraction of ANP and proANP-(1-30) from the plasma and ascites was accomplished by ...
- Ovarian cancer strikes one in 68 women: Now experts agree on a set of symptoms...
- Newspaper article from: Tulsa World (Tulsa, OK) August 2, 2007 700+ words
...estimated 15,000 Americans die of ovarian cancer, where malignant cells are found in...organs, the ovaries. For a long time, ovarian cancer was called the "silent killer" because...poor. Almost 70 percent of women with ovarian cancer are not diagnosed until the disease...
- Ovarian Cancer; Facts to Know.
- Newspaper article from: NWHRC Health Center - Ovarian Cancer March 16, 2005 700+ words
* What is ovarian cancer? There are almost 40 different types of ovarian cancer. However, nine out of 10 ovarian cancer patients have a common epithelial tumor, which begins in the surface tissue of the ovary (epithelium). * What causes ovarian...
- Ovarian Cancer
- Encyclopedia entry from: Gale Encyclopedia of Medicine, 3rd ed. Rastegari, Esther; Frey, Rebecca January 1, 2006 700+ words
Ovarian Cancer Definition Ovarian cancer is cancer of the ovaries, the egg-releasing and hormone...located. Although it is a distinct disease, it is linked with ovarian cancer. This is because the ovarian and peritoneal cells have the...
- Ovarian Cancer Does Have Early Warning Signs; Mayo Clinic and Olmsted Medical...
- News wire article from: AScribe Health News Service November 18, 2004 700+ words
...symptoms recorded in the medical records of ovarian cancer patients suggest ovarian cancer, long considered asymptomatic until late...urinary incontinence and abdominal pain. "Ovarian cancer is called 'the silent killer,'" says...
- Ovarian Cancer; Key Q&A.
- Newspaper article from: NWHRC Health Center - Ovarian Cancer March 16, 2005 700+ words
* What is ovarian cancer? There are almost 40 different types of ovarian cancer. However, nine out of 10 ovarian cancer patients have a common epithelial tumor, which begins in the surface tissue of the ovary (epithelium). * What causes ovarian...
- Ovarian Cancer.
- Clinical Reference Systems Cooper, Phyllis G. July 1, 1999 700+ words
What is ovarian cancer? Ovarian cancer is a malignant, life-threatening tumor that develops in...chance of complete cure. There are several different types of ovarian cancer. How does it occur? The cause of ovarian cancer is not...
- Ovarian Cancer: platinum-based therapy still the gold standard.
- Press release article from: M2 Presswire September 8, 2006 700+ words
...8 September 2006-DATAMONITOR: Ovarian Cancer: platinum-based therapy still the...of death from gynecological tumors, ovarian cancer does not attract the same level of...However, nearly 60,000 cases of ovarian cancer are being diagnosed in the seven major...
- Ovarian cancer genomic tests not reducing deaths.
- Newspaper article from: Medical Device Daily October 18, 2006 700+ words
Ovarian cancer genomic tests not reducing deaths...to diagnose and guide treatment of ovarian cancer are not shown to decrease the number...125 or BRCA1 and BRCA2 to diagnose ovarian cancer or identify women at risk. Among...
