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2002 MAY 15 - (NewsRx.com & NewsRx.net) -- A big challenge in vaccine design is how to trigger a protective immune response with the safest possible vaccine. Research into how Salmonella bacteria cause infection is leading to safer, more effective, vaccines against typhoid and other diseases, according to research reported in April 2002, at the spring meeting of the Society for General Microbiology at the University of Warwick, England.
Dr. Pietro Mastroeni of Cambridge University, U.K. said, "We have been studying the many ways in which new generations of live attenuated vaccines protect against disease. Producing an immune response against an infectious bacterium or virus is not always enough to give protection, and in some cases can worsen the disease."
Vaccine-induced immunity requires a sophisticated cross-talk between different parts of the immune system. Long lasting immunity relies on the presence and activation of species-specific T and B cells. Both T cell- and B cell-dependent immunity are needed to clear bacteria from tissues.
"This research is leading to more rational strategies to fight Salmonella infections in man and ...
Source: HighBeam Research, How do you make the perfect vaccine?(Salmonella bacteria...