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2002 MAY 16 - (NewsRx.com & NewsRx.net) -- Scientists studying how developing blood cells migrate to their proper destinations in fruit flies have discovered the ancestral role of a protein better known for ensuring that tumors have adequate blood supply.
The protein, called vascular endothelial growth factor (VEGF), has gained notoriety for guiding the development of new blood vessels that nourish cancerous tumors. When researchers block VEGF, the tumors' blood supply is cut off because new blood vessels don't form.
Now scientists say that VEGF and its receptors also help direct individual blood cells to their destinations in developing fruit fly embryos. The researchers say that this may be VEGF's ancient function, and that only recently in evolutionary time did VEGF assume its role in blood vessel development. …
Source: HighBeam Research, Experiments reveal ancient blood flow map.