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Wilms tumor gene expression marks stem cell graft contamination.
2002 MAY 16 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Acute myeloid leukemia (AML) cells express high levels of Wilms tumor gene 1 (WT1), which can be used to detect these cells in stem cell grafts, researchers say.
"High-dose chemotherapy with subsequent autologous stem cell transplantation is believed to be of therapeutic benefit in patients with acute myeloid leukemia (AML), especially when no allogeneic bone marrow donor is available," explained Dr. J. Siehl and colleagues at Benjamin Franklin University Hospital in Berlin, Germany. " One of the main risks is contamination of the stem cell preparations with leukemic blasts, which …
- Wilms tumor gene expression marks stem cell graft contamination.
- Magazine article from: Stem Cell Week May 13, 2002 700+ words
...levels of Wilms tumor gene 1 (WT1), which...detect these cells in stem cell grafts, researchers...detects elevated Wilms tumor gene (WT1) expression in autologous blood stem cell preparations (PBSCs...levels of Wilms tumor gene 1 (WT1), which...detect ...
- WT1 is a poor marker of post-SCT minimal residual disease.
- Newspaper article from: Cancer Weekly February 17, 2004 700+ words
...patients who undergo stem-cell transplantation (SCT...the use of the Wilms' tumor gene (WT1) as a minimal...levels after allogeneic stem cell transplantation. Bone...Institute, Center Allogene Stem Cell Transplantation, SE...
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...Stanford Institute for Stem Cell Biology and Regenerative...among patients whose tumor gene expression profiles correlated...suggest that this cancer stem cell gene signature may be...identified 186 cancer stem cell gene signature was observed...
- The genetics of Wilms' tumor - a case of disrupted development.
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...characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development. Mol. Cell. Biol. 11...tumors when the second allele is lost or mutated during retinal stem cell development. About 35-40% of children with retinoblastoma...
Source: HighBeam Research, Wilms tumor gene expression marks stem cell graft contamination.
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