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IgE shows activity on animal mast-cell sensitization.(immunoglobulin E)(Brief Article)
2002 MAY 8 - (NewsRx.com & NewsRx.net) -- by Lindsay Edmunds, PhD, ELS, senior medical writer - Experiments with a rat immunization model indicated unchanging levels, but increasing avidity and greater relative proportions, of antigen-specific serum immunoglobulin E, say scientists in Australia.
Researchers at the University of New South Wales investigated the effect of antibody affinity and nonspecific immunoglobulin E (IgE) on mast-cell sensitization in rats. IgE displayed the greatest biological activity on day 10, after which total serum IgE levels declined, although the relative proportion of specific IgE increased between days 10 and 15 (p
This proportionate increase was accompanied by an increase in the avidity of specific IgE (p
Possible explanations for these findings include "differential expression of IgE isoforms and changes in the fine specificity of the IgE response," according to the authors.
The corresponding author for this study ...
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