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Troybodies study shows promising results.(Brief Article)
2002 MAY 8 - (NewsRx.com & NewsRx.net) -- Affitech has converted its option into an exclusive worldwide license for the novel vaccine delivery technology, Troybodies. The company made the decision after early investigations demonstrated the ability of the technology to elicit a specific cellular immune response in vivo.
Affitech secured an exclusive option to Troybodies from the technology's inventors at the University of Oslo and the Norwegian National Hospital. This option will now be converted to an exclusive worldwide licence with unrestricted sublicense rights. As part of the option agreement, Affitech will enter into a research and development plan with the University of Oslo on cancer and autoimmunity.
The Troybodies technology utilizes specially engineered antibodies to position candidate antigenic T cell epitopes on MHC class II molecules of antigen presenting cells (APCs). This mechanism has been likened to a Trojan horse, as the T cell epitopes are hidden within ...
- A human dendritic cell-based method to identify CD[4.sup.+] T-cell epitopes in...
- Magazine article from: Environmental Health Perspectives Stickler, Marcia Mucha, Jeanette Power, Scott Harding, Fiona February 1, 2003 700+ words
...immunodominant CD[4.sup.+] T-cell epitopes in any protein. The method uses CD...food allergens, human donors, T-cell epitopes. Environ Health Perspect 111:251...allele. Interestingly, the same T-cell epitopes are capable of inducing either Th1...
- Antibodies Deliver T-Cell Epitopes to Antigen Presenting Cells.
- Newspaper article from: Immunotherapy Weekly June 4, 2000 700+ words
...recombinant antibodies (Abs) to deliver T-cell epitopes to antigen presenting cells (APC...an approach by which we target T-cell epitopes to APC by use of recombinant Abs...presentation was "Efficient delivery of T-cell epitopes to APC by use of engineered Abs...
- Antibodies Deliver T-Cell Epitopes to Antigen Presenting Cells.(Brief...
- Newspaper article from: Vaccine Weekly May 31, 2000 700+ words
...recombinant antibodies (Abs) to deliver T-cell epitopes to antigen presenting cells (APC...an approach by which we target T-cell epitopes to APC by use of recombinant Abs...presentation was "Efficient delivery of T-cell epitopes to APC by use of engineered Abs...
- Cellular Responses to T-Cell Epitopes Evaluated in Cameroon.(Brief Article)
- Newspaper article from: Vaccine Weekly April 5, 2000 700+ words
...responses to conserved and variant T-cell epitopes with vaccine potential in children...selected Plasmodium falciparum T-cell epitopes with vaccine potential." Quakyi et...responses to conserved and variant T-cell epitopes with vaccine potential in a Cameroonian...
- Naked DNA vaccine induces recognition of peroxidase T cell epitopes.
- Newspaper article from: Drug Week September 24, 2004 700+ words
...recognition of diverse thyroid peroxidase T cell epitopes According to a study from the United...Angeles and the Mayo Clinic. "Two T cell epitopes were immunodominant, one of which...potential correlation between T and B cell epitopes, we analyzed serum TPO antibody epitopic...
- Hepatoma hepatitis B virus variants collect in B- and T-cell epitopes of HBx.
- Newspaper article from: Hepatitis Weekly June 9, 2003 700+ words
...virus variants collect in B- and T-cell epitopes of HBx. "Hepatitis B virus (HBV...were found to coincide within the B-cell epitopes (positions 29-48), particularly...serine rich (PSR) domain, and the T-cell epitopes regions (positions 116-127...
- T- and B-cell epitopes in M. bovis antigen MPB70 induce immune response in mice.
- Newspaper article from: Tuberculosis Week April 14, 2003 700+ words
...amp; NewsRx.net) -- T- and B-cell epitopes in MPB70, a secreted Mycobacterium...tuberculosis." They screened MPB70 "for T-cell epitopes in four different inbred mouse strains...Journal of Immunology (T- and B-cell epitopes in the secreted Mycobacterium bovis...
- HLA-DR T cell epitopes of CEA identified colorectal cancer patients.
- Newspaper article from: Vaccine Weekly June 16, 2004 700+ words
...have identified functional HLA-DR T cell epitopes of CEA in patients with colorectal...investigators. "The defined HLA-DR T cell epitopes were spread over the entire CEA molecule...Immunotherapy (Functional HLA-DR T cell epitopes of CEA identified in patients with...