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Vaccine and drug combination eliminate viral DNA in some patients with HBV.(hepatitis B virus)(Brief Article)
2002 MAY 8 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Boosting immune system response with hepatitis B virus (HBV) vaccine may offer an advantage to some patients who are infected with the virus and receiving lamivudine therapy for it.
Inoculating those patients with vaccine containing HBV surface antigen (HBsAg) creates a situation where immune system cells secrete beneficial cytokines, augmenting the effects of lamivudine therapy, medical researchers in Germany at Johannes-Gutenberg-University announced in the April 2002 issue of Journal of Medical Virology.
In the European trial two groups of chronic hepatitis B patients received combination HBV vaccine/lamivudine therapy or combination HBV vaccine/lamivudine/interleukin (IL)-2 therapy. Each of the patients was tested for liver enzyme levels and viral makers before, during, and after trial completion.
"After the therapy was stopped, seven of nine vaccine/lamivudine and two of five vaccine/lamivudine/IL-2 recipients did not have detectable HBV DNA," reported Anja Dahmen and study coauthors.
Ultimately four patients demonstrated viral clearance although one experienced viral reactivation with spontaneous clearance shortly thereafter.
When Dahmen's team performed further tests on patient samples, ...
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Source: HighBeam Research, Vaccine and drug combination eliminate viral DNA in some patients...