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Uterine factor levels low in women with excessive menstrual bleeding.(Brief Article)
2002 APR 11 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Study authors in the United Kingdom have described uterine levels of angiopoietin-1 as being disproportionately low in women who have excessive menstrual bleeding, or menorrhagia.
Angiopoietin-1 is an angiogenic growth factor that binds to its receptor Tie-2 on endothelial cells. When uterine levels of angiopoietin-1 are thrown off balance, reparative mechanisms do not kick in, leaving menstrual bleeding unchecked, according to Peter Hewett and associates at the University of Birmingham Medical School, Edgbaston, Birmingham, U.K. The findings would suggest that therapy able to restore uterine angiopoietin-1 levels to normal might benefit women with menorrhagia.
While angiopoietin-1 is associated with vascular maturation, angiopoietin-2 is linked to vasculature immaturity, promoting neovascularization only when vascular endothelial growth factor is concurrently expressed. In fact, angiopoietin-2 acts as an antagonist to angiopoietin-1 by blocking the Tie-2 receptor, which causes vessel instability, Hewitt and colleagues explained.
The researchers examined angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2) and Tie-2 levels expressed by the endometrial tissues of similar numbers of women with or without menorrhagia in order to assess their roles in endometrial repair.
Several assays showed that Ang-2 levels were approximately the same in women with or without ...
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Source: HighBeam Research, Uterine factor levels low in women with excessive menstrual...