AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Aggressive ovarian cancer may be linked to blood disorder.(Brief Article)
2002 APR 11 - (NewsRx.com & NewsRx.net) -- Aggressive ovarian cancer may be linked to the presence of thrombocytosis, a blood disorder characterized by high platelet cell counts, report investigators at Cedars-Sinai Medical Center.
The findings, presented at the annual meeting of the Society of Gynecologic Oncologists, may lead to the development of more targeted therapies and help physicians to offer their patients more effective treatment options.
"Our findings show that thrombocytosis correlates with a more aggressive tumor biology in ovarian cancer and a poorer response to treatment," said Dr. Beth Karlan, Medical Director of the Women's Cancer Research Institute at Cedars-Sinai and senior author of the study. "Knowing which patients have this disorder in addition to their cancer, will enable us to select patients who might benefit from experimental and other treatment approaches."
Platelets, the smallest of the blood cells, are involved in clotting and enable the body to control bleeding. In normal conditions, platelet levels are regulated by factors in the bone marrow, but cancer cells may secrete substances that induce the marrow to produce platelets in excessively large quantities. In turn, platelets may then produce factors that cause cancer cells to grow or spread.
To determine whether thrombocytosis played a role in ovarian cancer tumor growth and metastasis, the investigators examined the records of 183 consecutive patients with and without thrombocytosis who had undergone surgery for advanced ovarian cancer. They found that 41 of the 183 patients demonstrated thrombocytosis prior to surgery and that those with the disorder had higher CA-125 levels, (a marker for ovarian cancer), more advanced-stage ...
- Aggressive ovarian cancer may be linked to blood disorder.
- Newspaper article from: Blood Weekly April 11, 2002 700+ words
...amp; NewsRx.net) -- Aggressive ovarian cancer may be linked to the presence...somehow linked to more aggressive ovarian cancer," said Karlan. "Our...is a reaction to more aggressive ovarian cancer or whether the disorder...
- Newly Discovered Gene May Predict Aggressive Ovarian Cancer.
- News wire article from: AScribe Health News Service September 29, 2005 700+ words
...to establish a role for the gene in ovarian cancer and may lead to a test that can predict...through the entire genome of seven ovarian cancer cell lines using a method developed...hopkinskimmelcancercenter.org Johns Hopkins Ovarian Cancer Center -- www.ovariancancercenter...
- Tumor Cells Practice Vascular Mimicry In Metastatic Disease.(ovarian cancer)
- Newspaper article from: Angiogenesis Weekly May 18, 2001 700+ words
...markers for consideration in ovarian cancer diagnosis and treatment strategies...net using the search term "ovarian cancer survial and mortality" yielded...reported in this study include: * Aggressive ovarian cancer cells engage in a process called...
- Homearama Charity House dedication honors young ovarian cancer survivor.(At...
- Newspaper article from: The Virginian Pilot August 8, 2009 700+ words
...s Hospital, where Sydney began treatment for aggressive ovarian cancer at 9 months old. Sydney's memories of infancy...she passed away," Sydney said of her friend. Ovarian cancer rarely affects children. Sydney's parents...
- Glycoprotein overexpression a biomarker of aggressive ovarian, uterine cancers.
- Magazine article from: Women's Health Weekly October 2, 2003 700+ words
...of women with aggressive uterine or ovarian cancer, researchers suggest. Ovarian and...usually better than for women with ovarian cancer; some women, however, will develop...of aggressive tumors for uterine and ovarian cancer. They reported their findings in the...
- Thrombocytosis linked to aggressive ovarian ca. (Cancer Recurrence Increased).
- Magazine article from: OB GYN News Worcester, Sharon May 1, 2002 700+ words
...aggressive tumor biology in patients with epithelial ovarian cancer, according to a recent retrospective study. That finding has immediate implications for the management of ovarian cancer patients with thrombocytosis. Specifically, because...
- Ovarian cancer strikes one in 68 women: Now experts agree on a set of symptoms...
- Newspaper article from: Tulsa World (Tulsa, OK) August 2, 2007 700+ words
...estimated 15,000 Americans die of ovarian cancer, where malignant cells are found in...organs, the ovaries. For a long time, ovarian cancer was called the "silent killer" because...poor. Almost 70 percent of women with ovarian cancer are not diagnosed until the disease...
- Ovarian Cancer
- Encyclopedia entry from: Gale Encyclopedia of Medicine, 3rd ed. Rastegari, Esther; Frey, Rebecca January 1, 2006 700+ words
Ovarian Cancer Definition Ovarian cancer is cancer of the ovaries, the egg-releasing and hormone...located. Although it is a distinct disease, it is linked with ovarian cancer. This is because the ovarian and peritoneal cells have the...
