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Vaccine development ends after complications arise in subjects.(Brief Article)
2002 APR 3 - (NewsRx.com & NewsRx.net) -- The maker of a highly touted experimental Alzheimer vaccine has ended development of the compound after 15 patients suffered serious brain inflammation.
But Elan Corp. said it still is pursuing vigorously a vaccine to slow worsening of Alzheimer and has other candidates that look promising in animal testing.
Still, the March 1, 2002, announcement marked a serious setback.
The Irish drug manufacturer excited researchers in 2000 when it discovered that in mice, the compound code-named AN-1792 could ward off and even reduce brain-clogging plaques that are a hallmark of Alzheimer disease.
Initial safety tests in people showed no adverse effects. But because the vaccine works by inducing the immune system to attack the protein that makes up those plaques, called beta amyloid, some scientists had warned that brain inflammation was a potential serious side effect.
In January 2002, Elan suspended the latest 360-patient ...
- Vaccine development ends after complications arise in subjects.(Elan...
- Newspaper article from: Pain & Central Nervous System Week April 1, 2002 700+ words
...after 15 patients suffered serious brain inflammation. But Elan Corp. said it still is...some scientists had warned that brain inflammation was a potential serious side effect...suffering an encephalitis-like brain inflammation. Since then, doctors have discovered...
- Companies expand brain inflammation research into live animals.
- Newspaper article from: Biotech Week March 26, 2003 700+ words
...collaboration to develop compounds to combat brain inflammation. Under the new agreement, Thuris...results in our in vitro models of brain inflammation. These successes lead us to conclude...likelihood that we may be able to block brain inflammation in vivo. We are pleased to see ...
- Thuris and Sigma-Tau Expand Brain Inflammation Collaboration Into Live Animals.
- Press release article from: PR Newswire March 3, 2003 700+ words
...collaboration to develop compounds to combat brain inflammation. Under the new agreement, Thuris...results in our in vitro models of brain inflammation. These successes lead us to conclude...likelihood that we may be able to block brain inflammation in vivo. We are pleased to see ...
- Parts of marijuana may fight dementia: Study: Drug reduces brain inflammation...
- Newspaper article from: Columbus Dispatch (Columbus, OH) October 19, 2006 700+ words
...marijuana boosted memory and reduced brain inflammation in rats with brains altered to mimic...and a 40 to 50 percent reduction in brain inflammation, Wenk said. "If we can cut their...but not make the patients high." Brain inflammation isn't the cause of Alzheimer...
- MRI can detect brain inflammation after cerebral infarction.
- Newspaper article from: Biotech Week September 29, 2004 700+ words
...inflammation in the brain after stroke and other pathologies. "Brain inflammation contributes to the tissue injury caused by ischemic stroke...an important tool for the noninvasive visualization of brain inflammation in stroke and other CNS pathologies," the researchers...
- Alzheimer's vaccine trial is suspended. (Biomedicine).(brain inflammation...
- Magazine article from: Science News February 16, 2002 700+ words
...researchers at Elan expanded their trial and began evaluating the vaccine's effectiveness. That's apparently when brain inflammation was detected in several of the participants. "Without details, it's hard to speculate.... They had to...
- Alzheimer's disease vaccine abandoned. (Biomedicine).(Elan Corp. ceases testing...
- Magazine article from: Science News March 16, 2002 700+ words
...Alzheimer's disease. Elan Corp. of Dublin now acknowledges that 15 people developed potentially dangerous brain inflammation after receiving vaccinations designed to clear their brains of the protein deposits thought to cause Alzheimer...
- Brain inflammation found in autism.
- Newspaper article from: Health & Medicine Week November 29, 2004 700+ words
2004 NOV 29 - (NewsRx.com & NewsRx.net) -- Inflammation in the brain is clearly a feature of autism, according to a new study. The researchers found strong evidence that certain immune system components that promote inflammation are consistently activated in people with autism. "These findings
