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DNA vaccine can provide mucosal protection.(Brief Article)
2002 APR 3 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - DNA vaccines may represent a safer and equally effective alternative to live, attenuated HIV vaccines, researchers in the United States argue.
"An effective vaccine against human immunodeficiency virus (HIV) should protect against mucosal transmission of genetically divergent isolates," explained Dr. Deborah Fuller and colleagues working with PowderJect Vaccines, Inc., in Madison, Wisconsin, the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania, and the Tulane Regional Primate Center in Covington, Louisiana.
Fuller and coauthors showed that a DNA vaccine could provide mucosal protection from the simian version of HIV.
The researchers evaluated the protective effects of a vaccine containing the genes coding for the SIV proteins Gag, Pol, and Env. A group of seven rhesus macaques were immunized with this vaccine, based on the 17E-Fr strain of SIV, they said.
Significant mucosal antibody and cytotoxic T lymphocyte activity were found in treated animals, study data showed. Nonmucosal CTL responses were also seen although serum antibody levels were insignificant.
More than half of the vaccinated animals were protected from infection with the DeltaB670 strain of SIV, whose env gene ...
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Source: HighBeam Research, DNA vaccine can provide mucosal protection.(Brief Article)