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Novel peptide may possess antifungal activity.(Brief Article)
2002 APR 4 - (NewsRx.com & NewsRx.net) -- A novel peptide derived from a molecule found in human saliva may be effective in treating a fungal infection, researchers in the University at Buffalo (UB) School of Dental Medicine have found.
The peptide, labeled MUC7 16-mer, has shown the capacity to kill strains of fungi in vitro that are resistant to most current antifungal treatments, making it a potential candidate for a new fungicide. The current study represents the first use of the peptide against a fungal pathogen in an animal model.
Results of the research were presented here March 9, 2002, at the International Association of Dental Research meeting.
The study, conducted by Giuseppe Intini, DDS, a doctoral student in the UB department of oral biology, involved mice infected with vaginal candidiasis, a fungal infection caused by the organism Candida albicans. Libuse Bobek, PhD, associate professor at the UB department of oral biology, supervised the research.
Three groups of three mice each were treated with the MUC7 16-mer peptide, Clotrimazole (the active ingredient in current antifungal medications) or placebo, respectively.
Intini's ...
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Source: HighBeam Research, Novel peptide may possess antifungal activity.(Brief Article)