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Hormone replacement therapy exacerbates genetic risk factors.(thrombosis)(Brief Article)
2002 APR 4 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Women with genetic predilictions for thrombosis should not be treated with hormone therapy, researchers in Europe warn.
"Hormone replacement therapy (HRT) increases the risk of venous thrombosis," explained Dr. Frits R. Rosendaal and colleagues at Leiden University Medical Center in Leiden, Netherlands, the Universities of Oxford and Reading in England, and the Royal Infirmary in Glasgow, Scotland.
The increased risk is particularly pronounced in women who carry thrombosis-related polymorphisms, Rosendaal and coauthors said.
They evaluated the effects of HRT on 77 middle-age volunteers, all of whom had recently experienced their first case of venous thrombosis. More than half (51%) of this cohort had received hormone treatments, according to the report, while HRT was reported in less than a quarter (24%) of women with no history of thrombosis.
The combination of HRT and the factor V Leiden mutation was expected to heighten the risk of thrombosis by just over sixfold, the researchers said. However, study data showed that women with both of these risk factors actually suffered from a thrombosis risk more than 15 times greater than that of other women.
Almost a quarter (23%) of the ...
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Source: HighBeam Research, Hormone replacement therapy exacerbates genetic risk...