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Dilution could extend vaccine supply without compromising effectiveness.(Brief Article)

Vaccine Weekly

| March 27, 2002 | COPYRIGHT 2002 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

1902 MAR 27 - (NewsRx.com & NewsRx.net) -- In the event of a bioterror attack using smallpox, health authorities could stretch out the nation's limited vaccine supply simply by diluting the 15 million doses that are on hand, a government official says.

Experiments to see whether diluted smallpox vaccine could still offer protection against the disease have been "very successful," said Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases.

Fauci spoke in Boston, Massachusetts at the annual meeting of the American Association for the Advancement of Science.

The dilution experiments tested vaccines that had been watered down to as little as one-tenth their original concentration on 650 volunteers. The data available so far do not show definitively that vaccines could be diluted that much and still prevent smallpox. But it is clear that a significant amount of dilution is possible, Fauci said.

Conclusive data were expected in ...

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Source: HighBeam Research, Dilution could extend vaccine supply without compromising...

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