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Subjects in vaccine study contract encephalitis.(Brief Article)
1902 MAR 27 - (NewsRx.com & NewsRx.net) -- Twelve Alzheimer disease patients injected with an experimental vaccine are now suffering serious brain inflammation.
The vaccine's manufacturer halted the experiment in January 2002 when it discovered that the first four patients, all from France, were suffering the encephalitis-like reaction.
Since then, doctors have discovered eight more people with the apparent side effect, which can be hard to distinguish from worsening Alzheimer, said Bill Thies of the Alzheimer's Association. All 12 are stable or improving, he said.
But the reactions raise serious questions about the future of Elan Corp.'s vaunted vaccine.
Elan excited researchers in 2000 when it discovered that in mice, the compound could ward off and even reduce brain-clogging plaques that are a hallmark of Alzheimer disease.
Initial safety tests in British patients showed no signs of serious side effects. But because the vaccine works by inducing the immune system to attack the protein that makes up those plaques, called beta amyloid, some scientists had warned that brain inflammation was a potential serious side effect. Thus, participants in the latest 360-patient study ...
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Source: HighBeam Research, Subjects in vaccine study contract encephalitis.(Brief Article)