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Suicide gene therapy shuts out existing tumors, prevents new ones.(Brief Article)
2002 MAR 13 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Using suicide gene therapy, scientists in France have been able to treat metastatic tumors and prevent the formation of new ones in rodent models of colon cancer.
The suicide cell gene therapy acted as a vaccine and in previous studies was shown to cause the reduction of distant tumors when injected directly into the liver, according to the researchers, who represent member institutes of the French investigational organization INSERM as well as other research facilities in France.
Suicide cell gene therapy consists of colon cancer cells that express cytosine deaminase. "Expression of the cytosine deaminase gene leads to the conversion of the nontoxic compound to 5-fluorocytosine to 5-fluorouracil," V. Pierrefite-Carle and coauthors, INSERM, said in Gut.
Investigators explained that in earlier animal studies, intrahepatic injection of the therapy and subsequent treatment with 5-fluorocytosine initiated the "regression of a distant wild-type liver tumor".
In their latest study, they used the same cells and 5-fluorocytosine but added subcutaneous injections to the treatment protocols in rodents with metastatic liver tumors.
"Subcutaneous and subcapsular vaccination induced 70% regression in the median volume of the preestablished liver tumor and abolished dissemination compared with control animals," Pierrefite-Carle and colleagues stated.
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Source: HighBeam Research, Suicide gene therapy shuts out existing tumors, prevents new...