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BCG vaccine elevates protective cytokine release.(Brief Article)
2002 MAR 13 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - The venerable and widely used Mycobacterium bovis Bacillus Calmette Guerin (BCG) tuberculosis vaccination raises protective cytokine output from immune cells, researchers in the United States report.
Dr. Amminikutty Jeevan and colleagues at the Texas A&M University System Health Science Center in College Station, Texas, and the National Cancer Institute in Frederick, Maryland, investigated the molecular effects of the BCG vaccine in animals.
The vaccine significantly heightens levels of cytokines linked to productive immune activity, Jeevan and coworkers found.
The researchers evaluated the mRNA expression of interleukin (IL)-1(beta) and regulated-upon-activation, normally T cell-expressed and -secreted chemokine (RANTES) in guinea pig cells. Stimulated spleen cells taken from BCG-treated animals showed a significant upregulation of these cytokines compared with cells taken from vaccine-naive guinea pigs, they said.
Similar results were seen in macrophages taken from inoculated animals, study data showed. However, the degree of IL-1(beta) and RANTES upregulation was markedly lower in macrophages infected with a virulent strain of tuberculosis.
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Source: HighBeam Research, BCG vaccine elevates protective cytokine release.(Brief Article)