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Pneumococcal vaccine boosters less effective for HIV patients.(Brief Article)
2002 MAR 13 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Booster doses of a commonly used vaccine against pneumococcal infections are markedly less effective in patients infected with HIV, researchers in the United States find.
Dr. Sybil A. Tasker and colleagues at the United States Naval Medical Center in San Diego, Quest Diagnostics, Inc.'s, Nichols Institute in San Juan Capistrano, California, and the Veterans Affairs Medical Center at the University of Minnesota School of Medicine in Minneapolis assessed the effectiveness of the 23-valent polysaccharide pneumococcal vaccine in HIV patients.
Reinoculation with this vaccine produced significantly weaker immune responses in HIV positive study participants, Tasker and team found.
The researchers compared vaccine-induced immune activity in HIV patients who received a booster shot more than 5 years after their original inoculation and in acutely infected HIV patients who were given their first vaccination. Pneumococcus-specific antibody responses were significantly reduced in reimmunized patients, they said.
Although booster doses of the pneumococcal vaccine were less effective, they did not appear to carry a significant risk of adverse effects. Complications were limited to fever, discomfort around the injection site, or both in a small proportion of patients, study data showed.
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Source: HighBeam Research, Pneumococcal vaccine boosters less effective for HIV patients.(Brief...