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Malaria vaccine based on parasite protein effective in animals.(Brief Article)
2002 MAR 13 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A vaccine based on a protein found on the surface of malaria-causing parasites protects animals from the disease, researchers in the United States and Japan report.
Hajime Hiseada and colleagues at the National Institutes of Health in Rockville, Maryland, and the University of Tokushima School of Medicine in Tokushima, Japan evaluated a "blood-stage vaccine based on Plasmodium falciparum merozoite surface protein 3 (MSP3)" in their study, published in the March 1, 2002 edition of the Journal of Infectious Diseases.
The vaccine studied was safe and effective in nonhuman primates, Hiseada and coworkers found.
They immunized seven Aotus nancymai monkeys with recombinant yeast expressing MSP3. Only one monkey required treatment for malaria after lethal Plasmodium falciparum challenge, compared with five of seven control animals, according to the report.
This MSP3 vaccine produced slightly better results than a vaccine based on merozoite surface protein (MSP) 1[subscript]42, study data showed. Two animals developed malaria after inoculation with an MSP1-based vaccine.
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Source: HighBeam Research, Malaria vaccine based on parasite protein effective in animals.(Brief...