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Multiantigen vaccine with recombinant gp160 effective in newly infected patients.(Brief Article)
2002 MAR 6 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers say that a multiantigen HIV vaccine, administered with recombinant gp160, can improve antiviral immune responses in acutely infected patients.
Dr. Xia Jin and colleagues at the Rockefeller University's Aaron Diamond AIDS Research Center in New York City, Aventis Pasteur in Lyon, France, and IDM Biotech in Montreal, Canada, assessed the efficacy of a canarypox vector vaccine in patients treated with early antiretroviral therapy.
This vaccine enhanced antibody and T-cell activity against a number of HIV antigens, they found.
Jin and coauthors studied 15 patients who had responded well to 2 years of highly active antiretroviral therapy (HAART), initiated within 120 days of symptomatic HIV infection. These volunteers were given a canarypox virus vector (ALVAC vCP1452) vaccine containing genes coding for several HIV proteins, with recombinant gp160 as an adjuvant, they said.
Almost all patients who completed the vaccine course showed significant and persistent improvements in antibody responses to HIV gp120 and/or p24 antigen, study data showed. Most patients also showed heightened antiviral T-cell activity although such improvement was transient.
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