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Cytotoxic T-cell activity crucial for persistently uninfected women.(Brief Article)
2002 MAR 6 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Cytotoxic T-lymphocyte activity protects women who remain uninfected with HIV despite extensive exposure, a finding that may be useful for vaccine development, researchers in the United States believe.
Dr. Joan H. Skurnick and colleagues at New Jersey Medical School in Newark, the University of Maryland in Baltimore, Rockefeller University's Aaron Diamond AIDS Research Center and New York University in New York City, the University of Alabama at Birmingham, and the University of California at San Francisco investigated the factors that confer such protection to women.
CD8 cell activity is the key factor, in both persistently uninfected women and in their infected partners, Skurnick and coauthors said.
The researchers examined a group of 17 women who remained free of HIV despite repeated sexual exposure to the virus. In addition, 12 of their infected male partners participated in the study, according to the report.
Most of the persistently uninfected women (13 of 17) demonstrated at least one immune response to HIV, such as CD8 cell cytotoxic or noncytotoxic activity, CD4 cell proliferation, or the release of interferon specific for the virus. However, study data showed that many immune responses to HIV, including antibody activity, single cell cytokine release, and reduced CD4 cell vulnerability, did not provide a significant degree of antiviral protection. One of the factors ...
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Source: HighBeam Research, Cytotoxic T-cell activity crucial for persistently uninfected...