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Potential vaccine boosts hope for pollen relief.(Brief Article)
2002 MAR 6 - (NewsRx.com & NewsRx.net) -- University of Melbourne scientists have developed a potential vaccine for hay fever and other pollen related allergies.
The breakthrough could provide a lifeline to the 25% of the world's population suffering severe allergic responses to pollen.
Working with a rye grass protein - one of the most potent environmental allergens known - the team, from the University's Plant Molecular Biology and Biotechnology Group, modified the gene responsible for its production.
The modified gene produced a protein that has a significantly reduced allergenic response, yet one still capable of boosting a person's immune response. These twin features are the key to a potential vaccine, or effective immunotherapy - the practice of giving allergic patients small, but increasing doses of allergen-containing extracts to boost their immunity to the allergen.
"Skin prick tests to assess the protein's safety suggest it is a significantly safer and more effective alternative to the current immunotherapy used to treat grass pollen allergies," said Associate Professor Prem Bhalla, joint leader of the group.
Their research is published in the European Journal of Immunology.
Current immunotherapy carries a significant risk of lethal side effects that include anaphylactic shock, a condition where the body rapidly becomes hypersensitive to an allergen.
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Source: HighBeam Research, Potential vaccine boosts hope for pollen relief.(Brief Article)