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U.K. Researchers Shed New Light On Cause of Recurrent Miscarriages.
2002 FEB 21 - (NewsRx.com & NewsRx.net) -- Women who carry a particular genetic mutation that predisposes them to blood clots have a significantly higher chance of miscarrying, according to U.K. researchers in a report in Human Reproduction (Factor V Leiden and recurrent miscarriage - prospective outcome of untreated pregnancies, Human Reproduction January 2002;17:442-445).
The first prospective study into the outcome of untreated pregnancies in a group of women carrying a mutation in the Factor V Leiden gene and with a history of recurrent miscarriages at around 12 weeks, showed that under 40% had live births compared with nearly 70% in a control group of women with a similar history but with a normal copy of the gene. (FVL is carried by 5% of Caucasians but is rarely found among Black people. It carries a fourfold risk of venous thrombosis and a 10-fold risk if the carrier is taking the oral contraceptive pill).
For women with the rogue gene who had a history of late miscarriage, only 1 out of 9 had a live birth compared with 22 out of 45 of the women with the normal gene.
The research was carried out by teams from the Department of Reproductive Sciences, Imperial College of Science, Technology and Medicine, London, and the Department of Haematology, St. Mary's Hospital NHS Trust, London.
Pregnancy complications associated with the mutated gene and other genetic mutations affecting the blood clotting mechanism are thought to be due to thrombosis in the blood vessels of the placenta.
Now the researchers have called for doctors to screen women for FVL mutations if they have a history of recurrent miscarriages associated with placental thrombosis. They also want targeted anti-blood clotting treatment for these women to be tested in a randomized clinical trial.
Dr. Raj Rai, clinical lecturer in reproductive medicine at Imperial College and coauthor of the study, said that it was important to stress that many women with the mutation had perfectly normal pregnancies, and that it was likely to be the women who had multiple risk factors for thrombosis who were most at risk of miscarrying.
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Source: HighBeam Research, U.K. Researchers Shed New Light On Cause of Recurrent Miscarriages.