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Ovarian Cancer-Specific Promoter Sensitizes Tumors To Cancer Drug.
2002 FEB 21 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Plasmid vectors expressing an ovarian cancer-specific promoter do a better job of directing gene therapy to ovarian tumors than some other vectors do, according to Fox Chase Cancer Center researchers.
The promoter is even more effective when delivered to cancer cells via cationic lipid particles, enhancing the effects of ganciclovir and extending survival in mice, the researchers say.
Rudi Bao and colleagues at the Philadelphia, Pennsylvania cancer center have developed a ovarian tumor-targeted gene therapy composed of a plasmid containing the ovarian specific promoter (pOSP1) and expressing the enzyme herpes simplex virus thymidine kinase (HSVtk). Their analysis of the novel gene therapy suggests problems such as the toxicity often experienced with using other promoters could be avoided with pOSP1-HSVtk.
Initially, Bao's group ascertained that the promoter was tissue-specific, using cancerous cells and noncancerous cells transfected with pOSP1-HSVtk to test for ganciclovir sensitivity. "OSP1-HSVtk could specifically sensitize the OVCAR3 ovarian caner cell line to GCV," they said.
After determining the plasmids were tissue specific, the researchers implanted transfected ovarian cancer cells into the abdominal cavities of severe combined immunodeficient (SCID) mice and followed those implantations with treatments of ganciclovir.
"SCID mice transplanted with the OVCAR3 transfectant and treated with ganciclovir survived longer than ...
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Source: HighBeam Research, Ovarian Cancer-Specific Promoter Sensitizes Tumors To Cancer Drug.