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Viral Library May Aid Vaccine Development.(Brief Article)
2002 FEB 20 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Japan and Thailand have developed an HIV viral library to facilitate the search for antiviral vaccines.
"A major hindrance in HIV vaccine development is the genetic diversity, a hallmark of HIV biology, and a poor understanding of how HIV vaccine prevents the emergence of escape variants during infection and progression of AIDS," explained Dr. Tetsu Mukai and colleagues at Osaka University's Research Institute for Microbial Diseases in Osaka, Japan, and the Thailand Ministry of Health in Nonthaburi.
Mukai and coauthors developed a technique for constructing a library of viral clones, according to their report in the January 2002 edition of the journal Vaccine.
The researchers used polymerase chain reaction (PCR) to amplify most of an HIV genome integrated into peripheral blood mononuclear cell DNA. A group of 93 different viral clones were created using this method, they said.
Of this group, 41 demonstrated the ability to replicate in peripheral blood cells, study data showed. Five clones triggered symptoms of HIV infection in host cells.
The parent virus, a subtype E strain common in Thailand, ...
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Source: HighBeam Research, Viral Library May Aid Vaccine Development.(Brief Article)