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Pneumococcal Surface Adhesin Shows Promise.(Brief Article)
2002 FEB 20 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States say that a pneumcoccal protein can induce potent antibacterial immune responses.
"Pneumococcal surface adhesin A (PsaA), a common protein expressed on all 90 pneumococcal serotypes, is a vaccine candidate," explained Dr. Scott E. Johnson and colleagues at the U.S. Centers for Disease Control and Prevention in Atlanta, Georgia.
PsaA peptides were highly immunogenic in a murine model, Johnson and coauthors reported.
The researchers evaluated the efficacy of three PsaA peptides in mice exposed to pneumococcal pathogens. They tested the effects of lipidating these peptides and compared mono- and multipeptide constructs, according to their report.
All of the PsaA peptide formulations induced the production of antibodies that inhibited nasopharyngeal carriage of pneumococcal serotypes 2, 4, and 6B, study data showed. The best results were obtained with lipidated and/or multipeptide constructs, which reduced pneumococcal carriage by up to 98%.
Nonlipidated and/or monopeptides also reduced bacterial carriage by a large ...
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- Pneumococcal Surface Adhesin Shows Promise.(Brief Article)
- Newspaper article from: Medical Letter on the CDC & FDA February 24, 2002 700+ words
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- Newspaper article from: TB & Outbreaks Week October 15, 2002 700+ words
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- Magazine article from: Emerging Infectious Diseases Vela Coral, Maria Claudia Fonseca, Nacxiry Castaneda, Elizabeth Di Fabio, Jose Luis Hollingshead, Susan K. Briles, David E. September 1, 2001 700+ words
Pneumococcal surface protein A (PspA) elicits protection in mice against...proteins, including pneumolysin, neuraminidase, pneumococcal surface adhesin A, and pneumococcal surface protein A (PspA), have been considered as alternative...
- Pneumococcal surface protein A and pneumolysin protect against pneumonia.
- Newspaper article from: Health & Medicine Week September 22, 2003 700+ words
...NewsRx.net) -- Immunizations with pneumococcal surface protein A and pneumolysin were protective...with recombinant forms of either pneumococcal surface protein A (PspA) or PdB (a genetically...Infectious Diseases (Immunizations with pneumococcal surface protein A and pneumolysin are ...
