AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Vaccine Combination Rejects Brain Tumor Establishment In Rodents.(Brief Article)
2002 FEB 20 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Using a combination of cytokine-based gene therapy and tumor cell vaccination, medical investigators have been able to produce immunity against brain tumors in rats.
The strategy of using a combination of therapies attempts to overcome previous problems seen in gene therapies meant for treating brain tumors, for it addresses the need for antigen presentation as well as sufficient immune cell recruitment, according to Y. Iwadate and associates at Chiba University Graduate School of Medicine in Japan.
"We investigated the therapeutic potential of induced systemic immunity in peripheral tissues combined with interleukin (IL-2) production in the vicinity of brain tumors to treat established brain tumors," described Iwadate and coworkers in Cancer Research.
To do that, researchers injected rodents intracerebrally with rat glioma cells (9L) that produced IL-2 (9L/IL-2) and subcutaneously with either irradiated 9L glioma cells or 9L/IL-2. Rats already growing 9L tumors were cured when treated with the combination therapy but not when they were treated with either the cytokine or vaccine therapies alone.
"Xenogeneic murine neuroblastoma cells secreting IL-2 could substitute for 9L/IL-2 cells, producing significant antitumor effects in the vaccinated rats," researchers said.
Investigators also observed more tumor-specific cytotoxic activity in dual-treated animals, and immune response ...
- Liposomal delivery offers clinical gene therapy for brain tumors.
- Newspaper article from: Cancer Weekly January 13, 2004 700+ words
...for the treatment of brain tumors, especially malignant...advanced medicine for brain tumors using liposomes containing...Clinical gene therapy for brain tumors. Liposomal delivery...Nagoya University, Graduate School of Medicine, Nagoya...
- Benign brain tumors of neurofibromatosis secrete vascular growth factor.
- Newspaper article from: Angiogenesis Weekly April 4, 2003 700+ words
...com & NewsRx.net) -- Benign brain tumors of neurofibromatosis secrete vascular...and colleagues, Nagoya University, Graduate School of Medicine. "VEGF immunostaining...contact K. Saito, Nagoya University, Graduate School of Medicine, Department of Neurosurgery...
- Brain tumors. (Update).
- Magazine article from: Physical Therapy Hill, Christina I Nixon, Cynthia S Ruehmeier, Jodie L Wolf, Lisa M May 1, 2002 700+ words
Brain tumors can affect people of all ages. (1) Unfortunately, the incidence of brain tumors is on the rise for all age groups, especially...Therapists who work with patients with brain tumors could benefit from knowing the pathophysiology...
- Researchers Explore the Link Between Everyday Chemicals and Brain Tumors.
- Press release article from: PR Newswire August 26, 2002 700+ words
...to chemicals that can increase their risk of brain tumors, according to researchers who will present...are researching for their possible links to brain tumors. "With brain tumors, studies increasingly show correlations between...
- UCLA Study Finds New Clues to the Orgins of Brain Tumors.
- News wire article from: Europe Intelligence Wire November 24, 2003 700+ words
...Jonsson Cancer Center have discovered that brain tumors may be derived from the cells that form...Our study suggests that pediatric brain tumors develop from cells that have many of...the National Academy of Sciences. "Brain tumors are notoriously difficult to treat and...
- Proxima Therapeutics Announces FDA Approval of GliaSite(R) Radiation Therapy...
- Press release article from: PR Newswire May 8, 2001 700+ words
...Thousands of Americans Diagnosed With Brain Tumors Each Year ALPHARETTA, Ga., May 8...Therapy System (RTS) treatment for brain tumors has received marketing clearance from...diagnosed this year with malignant primary brain tumors and nearly all will experience tumor...
- Stereotactic radiosurgery for metastatic brain tumors benefits selected...
- Newspaper article from: Medical Devices & Surgical Technology Week February 1, 2004 700+ words
...radiosurgery (SRS) for metastatic brain tumors is beneficial for patients with...prognosis of patients with metastatic brain tumors has been very poor so far because most patients with metastatic brain tumors had other metastatic lesions and...
- New Targeted Treatment for Brain Tumors Shows Promise in Pre-Clinical Models.
- Press release article from: PR Newswire February 15, 2006 700+ words
...Gliomas are the most common primary brain tumors, and also one of the most complicated...advancement in the treatment of malignant brain tumors, which are the number one cancer killer...emphasizing the important role HGF plays in brain tumors. About Brain Tumors Primary ...
- Stereotactic radiosurgery for malignant brain tumors: the patient's perspective.
- Magazine article from: Journal of Neuroscience Nursing Ward-Smith, Peggy April 1, 1997 700+ words
...multiforme are the most frequent primary brain tumors in the adult age group and represent...United States are diagnosed with primary brain tumors. It is also estimated that 13,300...15] Although primary malignant brain tumors constitute only about 2% of all cancers...
- BASIC SCIENCE: Polyoma Virus Linked to Brain Tumors.(Brief Article)
- Newspaper article from: Drug Discovery & Technology News March 1, 2002 700+ words
...association between a human polyoma virus and brain tumors has been established by a group of researchers...agnoprotein in samples of pediatric brain tumors, which may play a role in the development...function is unknown." T antigen may cause brain tumors in part by blocking tumor ...
Source: HighBeam Research, Vaccine Combination Rejects Brain Tumor Establishment In...