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Cytokine Immunizations Work Better When Local Tumor Irradiation Included.(Brief Article)
2002 FEB 20 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Cell factor vaccines that can prevent the growth of gliomas work better when the tumors are also treated with local radiotherapy, medical researchers in Hungary suggest.
Glioma cells (Gl261) transduced with genes for a number of cytokines worked well when administered as vaccines to tumor-implanted mice, but they worked even better when immunization was accompanied by local tumor irradiation, according to K. Lumniczky and colleagues, National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary. Since radiotherapy is often a primary or secondary treatment method for brain tumors such as gliomas, adding cytokine vaccines to patients' treatment regimens may open up new avenues for the treatment of such cancers.
"Vaccines producing either interleukin (IL)-4 or granulocyte macrophage-colony stimulating factor (GM-CSF) cured 20-40% of mice," Lumniczky and coworkers said of mice immunized with cytokines alone.
The vaccines were effective in a dose-dependent manner, stimulating tumor penetration by CD4[superscript]+ lymphocytes as well as with CD8[superscript]+ lymphocytes. With GM-CSF, removing the infiltrating lymphocytes reversed the vaccine's antitumor effects.
"Strong synergism was observed by combining cytokine vaccination (GM-CSF, IL-4, IL-12) with local tumor ...
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