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CD34-Enriched Stem Cell Grafts Hasten Recovery After Myeloablative Chemotherapy.
2002 FEB 14 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Hematopoietic stem cell grafts processed to minimize the number of CD34[superscript]- cells can improve recovery in advanced breast cancer patients undergoing high-dose chemotherapy (HDC), according to researchers in the United States.
J.L. Klein and colleagues working at Wayne State University's Barbara Ann Karmanos Cancer Center in Detroit, Michigan, evaluated the safety and efficacy of autologous, CD34-enriched stem cell grafts in women suffering from breast cancer with bone or bone marrow metastases.
Enriched stem cell grafts enabled quick hematological recovery from intense myeloablative chemotherapy, Klein and coauthors found.
A cohort of 50 volunteers underwent peripheral blood progenitor cell (PBPC) transplantation using grafts comprising magnetically isolated CD34[superscript]+ cells. The autologous grafts were reinfused into patients 2 days after HDC with cyclophosphamide, cisplatin and carmustine, according to the report.
Patients achieved neutrophil recovery in an median of 9 days, study data showed, with transfusion-independent platelet recovery seen in a median of 11 days. The most common form of morbidity was herpes zoster infection, seen in 23% of the patients studied.
The overall and progression-free ...
- Unrelated stem cell grafts effective after antithymocyte globulin treatment.
- Magazine article from: Stem Cell Week January 27, 2003 700+ words
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...NewsRx.com & NewsRx.net) -- Highly purified stem-cell grafts have low toxicity in children with non-cancerous...comes under the major subject areas of Hematology, Stem-Cell Transplantation and Transfusion Medicine. This article...
- Peripheral blood stem cell grafts may be linked to lower quality of life.
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- Cell grafts proceed, value uncertain. (fetal cell transplants)
- Magazine article from: Science News Weiss, Rick November 28, 1987 700+ words
Cell grafts proceed, value uncertain While scientists and public officials continue...suspected that many test animals would have recovered even without the cell grafts. Other studies call into question some of the microscopic evidence of...
- Pig-cell grafts ease symptoms of Parkinson's.(experimental use of pig brain...
- Magazine article from: Science News Seppa, N. March 25, 2000 700+ words
...neurologist at Boston University. Past work has found improvements in Parkinson's patients who got a sham surgery and no cell grafts. Dinsmore doubts that that could explain the recent patients' gains. The current research includes a sham surgery group...
- Experimental cell grafts for Huntington's.
- Magazine article from: Science News April 23, 1988 700+ words
Experimental cell grafts for Huntington's Physicians last week reported what appears to be the first surgical grafting of adrenal tissue into the brain...
- Potential Use of Embryonic Brain Cell Grafts in the Treatment of Hereditary...
- Newspaper article from: Generations Heckroth, John A. December 1, 1994 700+ words
My research program, funded in part by the National Ataxia Foundation, is designed to investigate the possible beneficial effects of embryonic nerve cell transplantation in a model of hereditary ataxia, the lurcher mutant mouse. The lurcher mutant mouse arose as a spontaneous genetic mutation which
Source: HighBeam Research, CD34-Enriched Stem Cell Grafts Hasten Recovery After Myeloablative...