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'One-Two Punch' Hits Key Growth Signal Pathway.(breast cancer treatment)
2002 FEB 14 - (NewsRx.com & NewsRx.net) -- Researchers at Vanderbilt University's Vanderbilt-Ingram Cancer Center have reported a successful "one-two punch" against breast cancer in cell and animal studies using two targeted therapies that interfere with a key growth signal pathway.
The findings, reported in the December 15, 2001, issue of Cancer Research, provide the foundation for a clinical trial in patients with metastatic breast cancer that produces too much of a protein called HER2/neu. This protein is the target for the antibody Herceptin.
Like the laboratory work, the clinical trial will combine Herceptin with another drug called ZD1839, or Iressa, that targets the epidermal growth factor receptor (EGFR), also known as HER1. The HER network transmits signals that lead to the overgrowth of cells that characterizes cancer.
In the laboratory, the researchers found that they could indirectly inhibit the activity of HER2 by directly inhibiting HER1. They also observed a greater rate of tumor cell death and greater tumor reduction by combining Herceptin and Iressa than by using either inhibitor alone.
"Both Herceptin and Iressa have minimal side effects," said Dr. Stacy L. Moulder, assistant professor of Medicine (Hematology/Oncology), lead author of the journal paper, and principal investigator of the clinical trial. "We're hopeful that we'll be able to use these drugs together to shrink tumors with fewer side effects."
Therapies that specifically target steps in the cancer development process are generating a great deal of excitement among clinicians, scientists, and patients. The U.S. Food and Drug Administration has approved two such treatments for cancer so far: Herceptin for a portion of breast cancer patients and Gleevec for a form of leukemia. However, many more, including Iressa, are being investigated against various types of cancer.
Although these drugs appear to provide great specificity with fewer side effects than traditional chemotherapy, there are many ...
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