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Insulin Levels Associate With Worst Outcomes In Early Breast Cancer.
2002 FEB 14 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Scientists have detected a link between insulin production and an excess risk for recurrence and death in women with early stage breast cancers.
Their report, published in the January 2002 edition of Journal of Clinical Oncology, implies the mitogenic effects of insulin may play a significant role in breast cancer carcinogenesis.
A team representing several facilities in Canada issued the report. According to Pamela J. Goodwin and colleagues, Mount Sinai Hospital, Toronto, Ontario, Canada, 512 women without diabetes, but diagnosed with early stage breast cancers, participated in the study. Acknowledging the association between insulin production and obesity, a cancer risk factor, researchers examined the women for fasting blood insulin levels, body size as measured by body mass index, and other cancer predictors.
"Fasting insulin was associated with distant recurrence and death; the hazard ratios and 95% confidence intervals (CI) for those in the highest (>51.9 pmol/L) versus the lowest (
The data indicated that the relationship between fasting insulin levels and outcomes in women with early stage cancer might not be linear, researchers said.
Investigators detected a significant interrelationship between insulin ...
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Source: HighBeam Research, Insulin Levels Associate With Worst Outcomes In Early Breast Cancer.