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Library Vaccine Shows Promise.(Brief Article)
2002 FEB 13 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - An HIV "library" vaccine has produced promising results in a murine model, researchers in the United States report.
"HIV-1 is a fundamentally difficult target for vaccines due to its high mutation rate and its repertoire of immunoevasive strategies," according to Rana A.K. Singh and colleagues at Baylor College of Medicine and Rice University in Houston, Texas.
A vaccine composed of a "library" of HIV gene fragments can induce immune responses to a high number of viral antigens, limiting its ability to escape through mutation, Singh and coauthors said.
The researchers studied a DNA vaccine constructed with all of HIV's open reading frames, the pieces of genetic code that can code for proteins or peptides. These open reading frames were expressed as antigen fragments attached to the ubiquitin protein to enhance proteasome antigen targeting, they said.
A single inoculation induced potent T cell responses to all 32 library antigens in human leukocyte antigen (HLA)-A*201-transgenic mice, study data showed. This response included cytotoxic T lymphocyte activity against immunodominant epitopes from all major HIV proteins, as well as HLA tetramer binding and interferon-expressing CD8 cell activity against other HLA-restricted epitopes.
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Source: HighBeam Research, Library Vaccine Shows Promise.(Brief Article)