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Placental DC-SIGN Expression May Enable In Utero Infection.
2002 FEB 7 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United Kingdom have identified a protein that may mediate mother-to-child transmission of HIV.
"DC-SIGN is a C-type lectin able to bind HIV gp120 with high affinity, mediating HIV adsorption to the surface of dendritic cells for up to several days," explained Elizabeth J. Soilleux and colleagues at Addenbrooke's Hospital in Cambridge.
This lectin may potentiate vertical HIV transmission, Soilleux and coworkers argued.
DC-SIGN expression was found on Hofbauer cells, placental macrophages that reside in the villus, they said. These cells expressed CD4, CCR5, and CXCR4, chemokine receptors used by HIV for cell entry. Macrophages from the decidua basalis also expressed DC-SIGN, according to the report.
Maternal blood, which also includes DC-SIGN[superscript]+ cells, is separated from Hofbauer cells and decidual macrophages by a layer of trophoblasts, the researchers noted. However, this trophoblast layer is ...
- NASA and University of North Dakota Sign DC-8 Agreement.
- Press release article from: PR Newswire June 2, 2005 700+ words
...Forks, to house and operate the agency's DC-8 jet aircraft. The purpose of the agreement...Center (NSERC) at the university with the DC-8 suborbital laboratory as the centerpiece...to expand the science conducted using the DC-8 and enhance hands-on educational opportunities...
- World Airways Signs DC-10 Cargo Contract With Ethiopian Airlines.
- Press release article from: PR Newswire December 28, 2006 700+ words
...Inc. , has signed a contract with Ethiopian Airlines to provide DC-10-30F cargo service between Addis Ababa, Ethiopia and Brussels...contract, valued at an estimated $6.8 million, will provide two DC-10 freighters, one for five months and one for three months...
- World Airways Signs Dc-10 Cargo Contract.
- Press release article from: PR Newswire January 12, 2006 700+ words
...wholly owned subsidiary of World Air Holdings, Inc. , has signed a contract with an international freight forwarder to provide DC-10-30F cargo service for nine months, through Sept. 30, 2006. "World Airways will operate five international round trips...
- Northern Trust signs DC distribution deal with Prudential.
- Newspaper article from: Financial News November 19, 2003 700+ words
...business to business at Prudential UK, said: "Research has identified that the corporate pensions market is looking for a bundled DC scheme administered by a single provider." Briggs said that Prudential had looked at Northern Trust, Frank Russell and SEI...
- Possibly a government agent holding inflammatory sign, pentagon, Washington....
- Picture from: Magnum Photos Elliott Landy January 1, 1967 700+ words
...agent holding inflammatory sign, pentagon, Washington. DC,1967. Keywords: outside...american geographical u s dc north american geographical...agent holding inflammatory sign, pentagon, washington. dc,1967. usa usa *bc library...
- Asurion Managed Wireless Signs Up DC Government.
- Press release article from: Business Wire February 28, 2005 700+ words
...Managed Wireless (AMW) group has entered into a contract to manage wireless devices for the District of Columbia government. The DC Government joins AMW's client roster which includes the Department of Homeland Security, Transportation Security Administration...
- Power Shack signs agreement.(DC Brands International signs distribution deal...
- Magazine article from: Mississippi Business Journal April 25, 2005 700+ words
BILOXI -- DC Brands International of Denver, which offers...of Power Shack. Dick Pearce, president of DC Brands, said, "Power Shack has placed an...Power Shack relationship is going to give DC Brands tremendous reach into the 'Mini Vegas...
- KWC signs four DC runners.
- Newspaper article from: Messenger-Inquirer (Owensboro, KY) April 19, 2007 700+ words
Byline: Jim Pickens Apr. 19--What occurred Wednesday afternoon in the Daviess County High School cafeteria brought a smile to the face of Panthers cross country coach Tony Rowe. Four DCHS athletes -- Cody Cliff, Brent Mesplay, Benji Whitehead and Chris Zachary -- signed national letters of intent
