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Hepatitis C Vaccine Enhanced By GM-CSF Gene Therapy.(Brief Article)
2002 FEB 6 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - A group studying hepatitis C virus DNA vaccines has found granulocyte macrophage-colony stimulating factor (GM-CSF) gene therapy increases their effectiveness in inoculated mice.
The group, lead by P. Ou-Yang, works in the College of Medicine at National Taiwan University of Taipei. According to their data, immune response was heightened in mice immunized with both agents.
"In this study, female Balb/c mice immunized with HCV core plasmid DNA with or without adjuvant GM-CSF cytokine gene could induce both cellular immune response and HCV core-specific antibody titers after injection," Ou-Yang and colleagues said.
More analysis revealed that in mice given both the DNA vaccine and the gene therapy, antibody titer, as well as cytotoxic T-cell activity, was greater.
Investigators believed the local lymph nodes of the inoculated mice played a key role in immune response activity because reporter protein, expressed after animals were treated with specially designed constructs containing reporter gene and cytokine gene plasmid, could be detected within inguinal nodes within a day of gene therapy administration, "especially in mice immunized with HCV/core plasmid plus ...
- Hepatitis C Vaccine Enhanced By GM-CSF Gene Therapy.
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- Gene Therapy Advisory Committee Annual Report published; UK leads Europe in...
- Press release article from: M2 Presswire January 31, 2003 700+ words
...31 January 2003-UK Government: Gene Therapy Advisory Committee Annual Report published...publication of the Eighth Annual Report of the Gene Therapy Advisory Committee (GTAC) for 2001...details of all proposals for clinical gene therapy studies reviewed by GTAC during the...
- GENE THERAPY.
- Magazine article from: The Exceptional Parent Meyers, Abbey S. March 1, 2000 700+ words
...1999, four days after receiving a gene therapy infusion at the University of Pennsylvania...first that could be directly linked to gene therapy--electrified the scientific community...have a powerful impact on the future of gene therapy experiments and how they are approved...
- Research and Markets: Gene Therapy - Technologies, Markets and Companies: New...
- Press release article from: Business Wire April 28, 2004 700+ words
...com) has announced the addition of Gene Therapy - Technologies, Markets and Companies to their offering. Gene therapy can be broadly defined as the transfer...genetically modified cells, the scope of gene therapy becomes much broader. Gene therapy...