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Vaccine Clinical Trials Underway.(Brief Article)
2002 JAN 30 - (NewsRx.com & NewsRx.net) -- Medarex, Inc., announced its multipronged tumor vaccine clinical program for the treatment of a variety of tumors, including advanced or incurable malignant melanoma.
Phase I/II clinical trials of two of these potential melanoma products are underway. This clinical program employs a series of different melanoma vaccines used in conjunction with MDX-010, Medarex's fully human antibody that binds to CTLA-4, a molecule associated with the suppression of normal immune responses to cancer.
The vaccines, which contain immune targets expressed by certain tumor cells, are designed to trigger a response from the patient's own immune system against his or her cancer. Currently, Medarex is pursuing clinical testing of MDX-010 in conjunction with two different melanoma vaccines, with additional vaccines expected to enter clinical trials during 2002.
CTLA-4 is a T-cell molecule that ordinarily ...
- MEDAREX ANNOUNCES PROMISING INTERIM DATA FROM PHASE I/II CLINICAL TRIALS OF...
- Press release article from: PR Newswire May 20, 1996 700+ words
...ongoing Phase I/II clinical trials of MDX-210 were presented...patients." "These clinical trials provide further evidence of MDX-210's potential...five products in human clinical trials, including MDX-210, which is being...
- Medarex Initiates Phase II Clinical Trials of MDX-010 for Metastatic Melanoma...
- Press release article from: PR Newswire October 29, 2002 700+ words
...initiation of two Phase II clinical trials of MDX-010, one in patients...brake, we believe that MDX-010 has broad potential...further in these Phase II clinical trials." Recent Clinical...0 mg/kg dose of MDX-010 alone may induce...
- Ipilimumab (MDX-010) Shows Encouraging Data in Phase I and Phase II Clinical...
- Press release article from: PR Newswire June 5, 2006 700+ words
...of ipilimumab (also known as MDX-010) in combination with...observed in other ipilimumab clinical trials. "The data reported from our...ipilimumab Ipilimumab (also known as MDX-010) is a fully human antibody...line study in combination with MDX-1379 (a melanoma peptide...
- Phase II Clinical Study of MDX-010/MDX-1379 Combination Shows Durable Responses...
- Press release article from: PR Newswire April 20, 2005 700+ words
...suppressing the immune response. MDX-010 is in clinical studies...cancer patients to fight tumors. MDX-010 is currently in a Phase...melanoma and in multiple Phase II clinical trials to investigate the product...types. The potential use of MDX-010 outside oncology is also...
- Bristol-Myers Squibb Company and Medarex Form Global Development and...
- Press release article from: PR Newswire November 8, 2004 700+ words
...first line therapy. MDX-1379 -- a melanoma...currently in Phase III clinical trials. Under the FDA Modernization...approval of the drug. MDX-010 is also currently in multiple Phase II clinical trials to test the product...The potential use of MDX-010 outside of oncology...
- Medarex Receives FDA Fast Track Designation for MDX-010 Treatment of Metastatic...
- Press release article from: PR Newswire October 5, 2004 700+ words
...fight tumors. In June 2004, MDX-010 received orphan drug designation...trial in melanoma patients, MDX-010 is currently being studied in a number of Phase II clinical trials in other oncology indications...cancer and renal cancer. An MDX-010 study for the treatment...
- Medarex Commences Enrollment in Phase III Clinical Trial for MDX-010 in...
- Press release article from: PR Newswire September 28, 2004 700+ words
...Medarex believes that the use of MDX-010 to block CTLA-4 also...effectively fight tumors. MDX-010 is also currently in multiple Phase II clinical trials to test the product for other...cancer. Outside of oncology, MDX-010 is also being explored...
- Medarex Announces Special Protocol Assessment Agreement with FDA to Initiate...
- Press release article from: PR Newswire August 23, 2004 700+ words
...fight tumors. In June 2004, MDX-010 received orphan drug...III and Stage IV melanoma. MDX-010 is also currently in multiple Phase II clinical trials to test the product for other...cancer. Outside of oncology, MDX-010 is also being explored...
Source: HighBeam Research, Vaccine Clinical Trials Underway.(Brief Article)