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DNA Prime With Sendai Virus Booster Effective.(Brief Article)
2002 JAN 30 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A Sendai virus-based HIV vaccine is effective when administered after a DNA prime, according to researchers in Japan.
"Heterologous prime/boost regimens are AIDS vaccine candidates because of their potential for inducing cellular immune responses," explained Tetsuro Matano and colleagues at the National Institute of Infectious Diseases' AIDS Research Center in Tokyo.
This strategy produced vigorous and persistent antiviral responses in animals, Matano and coauthors reported.
A cohort of rhesus macaques received a priming dose of env- and nef-deleted simian-human immunodeficiency virus (SHIV) proviral DNA, followed by a booster dose of recombinant Sendai virus expressing the HIV Gag protein. Animals treated with this regimen showed potent HIV specific T-cell activity, which lasted at least three months after inoculation, study data showed.
One week after challenge with the extremely virulent SHIV[subscript]89.6PD strain, vaccinated macaques displayed a vigorous and specific cytotoxic T-cell response not seen in vaccine-naive animals. Treated macaques did not suffer extensive CD4 cell loss after SHIV challenge, the researchers said, and maintained relatively low viral loads compared with their untreated counterparts.
Both components of the vaccine regimen induced specific cytotoxic T lymphocyte responses when given alone, but failed ...
- Sendai virus C protein prevents gamma-activated factor from binding.
- Newspaper article from: Biotech Week January 14, 2004 700+ words
...C-terminal half-fragment of the Sendai virus C protein prevents the gamma-activated...gamma-activated sequence site. "Sendai virus C protein associates with the signal...the anti-IFN-gamma mechanism of Sendai virus. The C-terminal half-fragment of...
- Nucleocapsid-binding domain of Sendai virus phosphoprotein reported.
- Newspaper article from: Proteomics Weekly May 10, 2004 700+ words
...nucleocapsid-binding domain of the Sendai virus phosphoprotein in solution in a recent...RNA-dependent RNA polymerase of the Sendai virus (SeV) consists of the large protein...nucleocapsid-binding domain of the Sendai virus phosphoprotein in solution. Virology...
- Sendai virus expressing RSV glycoprotein elicits immune protection.
- Newspaper article from: Respiratory Therapeutics Week August 2, 2004 700+ words
...amp; NewsRx.net) -- Recombinant Sendai virus expressing the G glycoprotein of respiratory...murine parainfluenza virus type I (Sendai virus [SV]) as a xenogeneic vector to deliver...the Journal of Virology (Recombinant Sendai virus expressing the G glycoprotein of respiratory...
- Recombinant Sendai virus provides for efficient gene transfer into stem cells.
- Newspaper article from: Virus Weekly March 18, 2003 700+ words
...amp; NewsRx.net) -- Recombinant Sendai virus provides for efficient gene transfer...transfer agent, namely recombinant Sendai virus (SeV), and we have here characterized...study in Gene Therapy (Recombinant Sendai virus provides a highly efficient gene transfer...
- Recombinant Sendai virus delivers genes to human airway epithelium.
- Newspaper article from: Biotech Week April 7, 2004 700+ words
...NewsRx.net) -- Recombinant Sendai virus delivers genes to human airway epithelium. "Recombinant Sendai virus (rSeV) infects respiratory epithelial...Experimental Lung Research (Recombinant sendai virus for efficient gene transfer to human...
- Studies from Aarhus University reveal new findings on sendai virus.
- Newspaper article from: Virus Weekly June 16, 2009 700+ words
...in Aarhus, Denmark report (see also Sendai Virus). "Here we have investigated the...in innate immune responses induced by Sendai virus, a negative sense single-stranded...fibroblasts and DCs after infection with Sendai virus in a manner dependent on virus replication...
- F-deficient Sendai virus vector is less toxic to fetal tissue.
- Newspaper article from: Drug Week May 21, 2004 700+ words
...amp; NewsRx.net) -- F-deficient Sendai virus vector is less toxic to fetal tissue...dependent on genomic integration, such as Sendai virus vectors (SeVV). Prenatal gene therapy...Reduced toxicity of F-deficient Sendai virus vector in the mouse fetus. Gene Therapy...
- Scientists at University of North Carolina release new data on sendai virus.
- Newspaper article from: Virus Weekly March 31, 2009 700+ words
...the Mononegavirales, we examined the Sendai virus (SeV) (family Paramyxoviridae) L...University of North Carolina (see also Sendai Virus). The researchers concluded: "The...Journal of Virology (Identification of Sendai Virus L Protein Amino Acid Residues Affecting...
- Key steps optimize the propagation of gene deleted Sendai virus vectors.
- Newspaper article from: Health & Medicine Week March 29, 2004 700+ words
...the propagation of gene deleted Sendai virus vectors. According to a study from Germany, "recombinant Sendai virus vectors (SeVV) have become an...single gene deleted recombinant Sendai virus vectors. Virus Res, 2004;99...
- Scientists at Case Western Reserve University discuss research in sendai virus.
- Newspaper article from: Virus Weekly October 28, 2008 700+ words
...intraperitoneal priming with inactivated Sendai virus (SeV) emulsified in either complete...Western Reserve University (see also Sendai Virus). The researchers concluded: "We...Immunology, Nephrology, Nephropathy, Sendai Virus, Virology, Case Western Reserve University...
Source: HighBeam Research, DNA Prime With Sendai Virus Booster Effective.(Brief Article)