AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Mucosal Administration Can Improve Vaccine Efficacy.(Brief Article)
2002 JAN 30 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Mucosal administration of HIV vaccines can improve the protection they offer, researchers in the United States report.
Igor M. Belyakov and colleagues at the National Institutes of Health in Bethesda, Maryland, the Wisconsin Regional Primate Center in Madison, Wisconsin, the Emory University Vaccine Center in Atlanta, Tulane University in New Orleans, Epimmune, Inc., in San Diego, and Advanced BioScience Laboratories, Inc., in Kensington, Maryland, evaluated the effect of delivery route on the efficacy of HIV vaccines.
They found that mucosal administration enhanced the potency of vaccine-induced antiviral immune responses, according to their study published in Nature Medicine.
The researchers exposed rhesus macaques to the Ku2 strain of simian-human immunodeficiency virus (SHIV) after inoculation with a synthetic peptide-based vaccine. The animals were given the vaccine either subcutaneously or intrarectally, they said.
Macaques who were vaccinated through the rectal mucosa achieved significantly lower viral loads and better CD4 cell preservation compared with animals who were received subcutaneous vaccination, study data showed. Viral RNA in rectally treated macaques was reduced to undetectable levels in the intestine, a "major reservoir for virus replication," ...
- STD Quarterly: HIV vaccines: New generation may reduce transmission of virus.
- Magazine article from: Contraceptive Technology Update October 1, 2002 700+ words
STD Quarterly: HIV vaccines: New generation may reduce transmission...of Health (NIH), six potential HIV vaccines were tested during the past five...new generation of T cell-based HIV vaccines also offers promise in delaying...
- Brazil to test and develop HIV vaccines.
- Newspaper article from: South American Business Information February 21, 2003 700+ words
...enter the group of few countries who currently develop the HIV vaccines. The Ministry of Health is will direct extra budget to create...universities that have projects to develop their own anti-HIV vaccines. The Ribeiro Preto-based unit of USP university (Universidade...
- NIH Disperses Nearly $90M For HIV Vaccines, Other Diseases.(National Institute...
- Magazine article from: BIOWORLD Today Lorenzo, Aaron September 30, 2003 700+ words
...64.3 million in development funds for work related to HIV vaccines - Progenics Pharmaceuticals Inc. was awarded $28.6 million...funding toward the design and development of prophylactic HIV vaccines for clinical evaluation by the NIAID-sponsored HIV Vaccine...
- Progenics and ADARC Discover Promising New Class of HIV Vaccines.
- Press release article from: PR Newswire January 11, 2000 700+ words
...stemming the worldwide spread of AIDS. However, experimental HIV vaccines developed to date are largely ineffective against wild type...an important milestone in the search for new and effective HIV vaccines," said Paul J. Maddon, M.D., Ph.D., Progenics...
- HIV vaccines reduce chance of infection
- Newspaper article from: Charleston Gazette Steve Goldstein September 25, 2009 700+ words
LONDON - A late-stage trial combining two HIV vaccines was shown to reduce the chance of infection by one third, raising the prospects that in time AIDS can go the way of polio as an...
- HIV vaccines: the future looks promising.(Perspectives)
- Magazine article from: Research Initiative/Treatment Action! Lewis, Dorothy E. January 1, 2007 700+ words
...by T cells. Both of these strategies--virus-based vectors and naked DNA-based vectors--are under evaluation for HIV vaccines. The virus-based vectors include those that are based on adenovirus and pox virus, both of which are being studied in...
- Stalled HIV vaccines given a shot in the arm.(Animal trials)(human...
- Magazine article from: Chemistry and Industry Walter, Patrick November 24, 2008 700+ words
...but wonders if HIV's variability may defeat this approach. However, this specific system is unlikely to be used in HIV vaccines. Merck's failed vaccine trial found that those who received the vaccine had higher rates of HIV infection, suggesting...
- While therapeutic HIV vaccines remain at an early stage, they may have a...
- Magazine article from: Inpharma Weekly Anonymous August 16, 2008 700+ words
While therapeutic HIV vaccines remain at an early stage, they may have a potential role to play in the management of patients with HIV, says Jonathan Angel...
Source: HighBeam Research, Mucosal Administration Can Improve Vaccine Efficacy.(Brief Article)