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Cytokine Helps Embryos Resist Harmful Effects Of Diabetes.(transforming growth factor-beta 2)
2002 JAN 24 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Medical researchers have concluded that the presence of transforming growth factor (TGF)-(beta) 2 in the uterus enables embryos to overcome the teratogenic effects of diabetes.
That conclusion, based on animal model experimentation, provides important clues about the nature of diabetes, embryonic loss, and the immune response system in diabetic females.
"Cytokines and growth factors operating in the embryonic vicinity are found to be among factors that determine the sensitivity of embryos to external and internal detrimental stimuli, including diabetes," noted A. Fein and coauthors, Sackler School of Medicine, Tel Aviv, Israel, in Teratogenesis, Carcinogenesis, and Mutagenesis.
Because uterine TGF-(beta)2 expression is thought to be essential for embryogenesis, Fein and associates elected to study its expression patterns in mice with induced (streptozotocin) diabetes. They found that diabetic mice expressed less TGF-(beta)2 mRNA and protein within the first nine days of pregnancy, and produced more litters with malformed fetuses.
They also studied the effect of immunopotentiation on TGF-(beta)2 expression levels in diabetic mice after finding that stimulating the maternal immune response system increased embryonic resistance to the effects of diabetes (Diabetes teratogenicity in mice is accompanied with ...
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Source: HighBeam Research, Cytokine Helps Embryos Resist Harmful Effects Of...