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Study Identifies Signaling Gene For Immune Cells.(Brief Article)
2002 JAN 23 - (NewsRx.com & NewsRx.net) -- More vigilant than minutemen, the immune system's T cells form one of the main lines of defense against infection and disease.
A study by Dana-Farber investigators is reversing scientists' understanding of how the cells are alerted to enemy invaders.
Researchers led by Vassiliki Boussiotis, MD, PhD, found that a signal from a gene called Tob keeps the cells in a dormant, or "quiescent," state. Only when that gene is shut off - when an infection is afoot - do the cells become activated against disease.
"The quiescent state isn't something the cells lapse into, as had been previously thought, but one they must actively maintain," Boussiotis says. The finding has direct ...
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